For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

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For our Biologics site located in Erkrath, Germany we are seeking

an experienced

Scientist as a Mass Spectrometry & Proteomics Specialist (m/f/d)

Responsibilities

Implement and qualify mass spectrometry equipment at different Charles River sites in Germany and USA
Develop and implement highly complex and state-of-the-art mass spectrometry-based methods to identify, characterize, and quantify proteins from complex protein mixtures.
Operate and maintain high-resolution tandem mass spectrometers such as Thermo Scientific Orbitrap Exploris, Lumos, and Q-Exactive and the requisite nano-scale liquid chromatography and capillary electrophoresis systems.
Identify, advise or assist investigators with developing strategies for sample preparation for the use of gel electrophoresis, liquid chromatography, capillary electrophoresis, and mass spectrometry to identify, quantify, and characterize proteins and their modifications
Perform routine testing in techniques such as the following with a degree of reliability, efficiency and accuracy.
- Total proteomics, identification and quantification of host cell proteins (HCP)
- Targeted peptide quantification
- Peptide Mapping by LC-UV/MS (MS)
- Intact Molecular Weight Analyses by LC-UV/MS
- Sample preparation techniques including protein concentration determination, SDS PAGE, SPE, HPLC Fraction Collection
- Glycosylation site Mapping
- Released N- and O- Linked Glycosylation Profiling
- Residuals and impurities investigations
- Methodologies developed for Orbitrap, QTOF, and Triple Quadrupole
Teach staff, students, or fellows advanced techniques in protein analysis by mass spectrometry used in the center through informal discussions or formal workshops offered by the facility.
Expand or develop new skills, as needed, based on information from literature, in collaboration with other laboratories or vendors, or by interacting with colleagues at meetings or professional presentations.
Responsible for maintaining high-end mass spectrometers, developing and following SOPs, developing and maintaining collaborative connections with the investigators.
Independent research in technological developments in proteomics will be strongly encouraged.

Qualifications

This position would suit an ambitious, flexible, and team-orientated individual who is motivated to achieve results. The main base of this position would be Erkrath, Germany.

You will also be expected to have:

Education: Bachelor’s degree (B.A. /B.S.) or equivalent in Chemistry/ Biochemistry or related scientific discipline. M.S. or Ph.D. preferred.
Experience in Top-Down proteomics, targeted proteomics (SRM/MRM), quantitative proteomics, glycoproteomics and phosphoproteomics is preferred.
Knowledge of mass spectrometry, protein separation, and identification methods.
Experience in leading and motivating people
Willingness to travel to EU and non-EU based Charles River sites as needed
Strong organizational skills and talent to drive operations in a fast-changing environment
Ability to promote constructive and open collaborations and interactions with experts and between different teams in a (matrix) organization
Very good communication and presentation skills to effectively communicate with various target groups
Fluency in both English and German (oral and written)

What we offer

an unlimited full-time position with varied, demanding activities
a future-oriented global industries and company
flexible working hours
an active participation in shaping your field of activity in a motivated team

Are you interested?

Please apply under job ID 222151 via our career portal with your application documents in English and your earliest possible starting date.
We look forward to receiving your application!

Charles River Laboratories Germany GmbH
Human Resources
Max-Planck-Str. 15a
40699 Erkrath
Phone: 0211 9255-356 (Michaela Klein)

About Biologics Testing Solutions
With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs. Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021.

Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, or national origin, veteran or disability status.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

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